Sirtuin-1 regulation of mammalian metabolism
نویسندگان
چکیده
منابع مشابه
Sirtuin-1 regulation of mammalian metabolism.
Sirtuin-1 (SirT1) is a nutrient-sensing deacetylase whose levels and activity increase with caloric restriction to preserve euglycemia and promote efficient energy utilization. Focusing on data obtained in vivo, we review how SirT1 orchestrates the adaptive response to fasting by stimulating hepatic gluconeogenesis and fatty acid oxidation, increasing circulating adiponectin levels and limiting...
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ژورنال
عنوان ژورنال: Trends in Molecular Medicine
سال: 2011
ISSN: 1471-4914
DOI: 10.1016/j.molmed.2010.09.005